Aging Research Headlines
Google Creates Calico Labs to Study Aging Research
California Life Company, or Calico Labs for short, was started by the founders of Google. Calico was created as an "academic-biotech hybrid" that studies lifespan and the biology behind the aging process. An article in MIT Technology Review takes a closer look at Calico's work and the emerging field of aging research startups. Read the full article here.
Dementia Rates in the U.S. Are Declining, Researchers Say
A team at the University of Michigan has published a study that said that the number of American seniors with dementia is declining. The study also found that diabetes, hypertension, and obesity may increase the risk of dementia. The findings published in JAMA Internal Medicine reveal that people with higher levels of education had the lowest chances of developing dementia. To learn more, go here.
Potential Factor in Age-Related & Alzheimer's Related Memory Loss May Be Uncovered, Researchers Say
Scientists at The Scripps Research Institute (TSRI) found that decreased levels of a protein called Rheb was linked to memory loss in animal models and increased levels of the enzyme BACE1, which is often high in patients with Alzheimer's disease. TSRI researchers say they are hoping to target the Rheb pathway to allow for potential treatments for "aging or Alzheimer's disease-associated memory deficits." To learn more, go here.
Centenarians May Hold Key to Aging, Says Geneticist
During a recent presentation at TEDMED, Dr. Nir Barzilai of the Albert Einstein College of Medicine said that centenarians may help understand the science behind aging. Barzilai and his research team studied hundreds of people ages 100 and older, finding that the centenarians seemed to develop illnesses much later in life, compared to noncentenarians. Barzilai also highlighted how metformin, a drug used to control diabetes, may change the rate of aging. To learn more, go here.
Positive Attitudes May Be Linked to Longer Lifespan in Women, Researchers Say
Researchers at Harvard University studied more than 70,000 women to examine the link between optimism and premature death. The researchers found that the most optimistic women were 29 percent less likely to die of any cause than the least optimistic women. “While most medical and public health efforts today focus on reducing risk factors for diseases, evidence has been mounting that enhancing psychological resilience may also make a difference,” said Eric Kim, co-author of the study. To learn more, go here.
Progeria Research Foundation Seeks Proposals for Research on Hutchinson-Gilford Progeria Syndrome, March 21, 2017
The Progeria Research Foundation (PRF) is the only organization in the world dedicated to discovering treatments and the cure for Progeria and its aging-related disorders. Progeria is a rare, fatal, "premature aging" disease that affects children, who die of heart disease (heart attacks or stroke) at an average of 14 years - the same heart disease that affects millions of normal aging adults.
PRF encourages proposals in the areas listed below. Investigators are not limited to applications that address these priorities, but rather are encouraged to use them to better understand the needs of the field at this time.
PRF is seeking proposals that address the following priorities:
1. Discovery of biological markers of disease in HGPS that can be assessed in human and/or mouse samples. Highest priority will be given to those markers that can be assayed in easily obtainable human samples such as blood, urine, and cheek swabs. In addition, proposals that explore biomarker relevance to disease process and /or change in markers with disease treatment are encouraged.
2. Discovery and/or testing of candidate treatment compounds in both cell based and mouse models of HGPS. Of note, proposals should test compounds in a progerin-producing mouse model as the priority. Comparisons to other mouse models of disease, such as ZMPSTE24 -/- and other non-progerin producing mouse models is acceptable, but only as a comparison to progerin-producing models.
Visit the PRF Web site for complete program information.